A Limited Sampling Strategy for Estimating Sirolimus Area-Under-the-Concentration Curve
نویسندگان
چکیده
منابع مشابه
A limited sampling strategy for estimating sirolimus area-under-the-concentration curve.
Area-Under-the-Concentration Curve, Bruce Kaplan,* Herwig-Ulf Meier-Kriesche, Kimberly Napoli, and Barry D. Kahan (Div. of Renal Dis. and Hypertension, Dept. of Internal Med., and Div. of Immunol. and Organ Transplant., Dept. of Surgery, The University of Texas Medical School at Houston, 6431 Fannin, Suite 4.163, Houston, TX 77030; *author for correspondence and reprint requests: fax 713-794-1197)
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Antitumor activity of topotecan, a new derivative of camptothecin, has been documented in many tumors. The active lactone form of topotecan is in equilibrium with the inactive hydroxyacid form. However, dose-limiting toxicity, neutropenia, is correlated to the area under the concentration time curve (AUC) of not only the lactone form but also total (lactone + hydroxyacid) topotecan. Because the...
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H. Tsuruta1; M. Fukumoto2; L. Bax3; A. Kohno4; Y. Morishita4 1Department of Medical Informatics, School of Allied Health Sciences, Kitasato University, Kanagawa, Japan; 2Division of Toxicology, Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan; 3Pharsight Corporation, Sunnyvale, CA, USA; 4Department of Hematology and Oncolog...
متن کاملLimited sampling strategies to estimate the area under the concentration-time curve. Biases and a proposed more accurate method.
BACKGROUND Over 100 limited sampling strategies (LSSs) have been proposed to reduce the number of blood samples necessary to estimate the area under the concentration-time curve (AUC). The conditions under which these strategies succeed or fail remain to be clarified. OBJECTIVES We investigated the accuracy of existing LSSs both theoretically and numerically by Monte Carlo simulation. We also...
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We previously established a limited sampling model (LSM) for the area under the concentration versus time curve (AUC) of irinotecan (CPT-11). Using this LSM, we performed a pharmacokinetic-pharmacodynamic analysis of CPT-11 in a multicentric Phase II study for non-small cell lung cancer. Ten institutes participated in this study, 36 patients were registered, and 30 patients were evaluable for t...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 1997
ISSN: 0009-9147,1530-8561
DOI: 10.1093/clinchem/43.3.539